Henry removed Wolsey as his advisor and had him arrested because the cardinal had failed to persuade the pope to grant the divorce between himself and Catherine of Argon. Henry stated if Wolsey did not die of natural causes on his way to prison he'd have him executed for treason.
He found ways to exile anyone he possibly could and charge them for treason. By 1531 he declared high treason meant exile by poison or even boiling to death. Henry was often said to be unfaithful to even his closest friends and he never shed tears over deaths.
Before Elizabeth reached her third birthday, her father had her mother (Anne Boleyn) beheaded on charges of adultery and treason, these were false accusations solely created because she hadn't birthed a male heir resulting in Henry to become bored.
"Touching her innocency alway to be clear... I have seen many men and also women executed, and that they have been in great sorrow, and to my knowledge this lady has much joy in death."-a letter from Sir W. Kingston, Constable of the Tower, to Thomas Cromwell from Anne Boylen on the day of her execution
"Good Christian people, I am come hither to die, for according to the law, and by the law I am judged to die, and therefore I will speak nothing against it. I am come hither to accuse no man, nor to speak anything of that, whereof I am accused and condemned to die, but I pray God save the king and send him long to reign over you, for a gentler nor a more merciful prince was there never: and to me he was ever a good, a gentle and sovereign lord. And if any person will meddle of my cause, I require them to judge the best. And thus I take my leave of the world and of you all, and I heartily desire you all to pray for me. O Lord have mercy on me, to God I commend my soul." -Anne Boylen speech right before execution
Catherine Parr exiled for flirtations with other men
Even though Cromwell arranged Anne of Cleves to marry Henry, but 6 months later he was executed because he disliked her so much.
Catherine Howard's uncle, Thomas Howard, was found guilty of treason and sentenced to death. This was only abandoned due to the death of Henry VIII.